Continuing a collaboration with actor/restaurateur Robert De Niro that began in 1994, when the first Nobu restaurant opened, in New York's Tribeca, superstar chef Nobu Matsuhisa has created a 181-room boutique property in the old Centurion Tower of Caesars Palace, bringing much-needed Zen to the hyperactive Vegas Strip. Architect David Rockwell's carefully curated interiors mix peaceful, neutral colours and natural materials, ushering guests into a world of quiet privilege far removed from Caesars' dazzlingly noisy gaming floor. With its elegant simplicity and pared-back luxe, Nobu is one of the few things in Vegas that's a sure bet.

In the standard 350 sq ft Nobu Deluxe King room (pictured), contemporary Japanese artwork floats serenely across a large canvas above an extraordinarily comfortable king-sized bed immaculately dressed in white Fili D'oro linens. A tap at the door and a maid quietly sets down a small wooden tray containing a porcelain pot of iced green tea and Oedo crackers. Using a super-smart, very large television, guests can make a booking at Qua spa or reserve a table at Nobu restaurant (pictured) - which can, alternatively, be done from anywhere by smartphone, assuming the user has downloaded the appropriate app. The bathroom's walk-in, black-tiled shower is spacious and the stylish black and white take-home Japanese slippers slide neatly into a suitcase. One- or two-bedroom Hakone suites feature separate living and dining areas with walk-in dressing rooms. Six Sake suites (pictured) each incorporate a billiard table and separate entertainment/media rooms, while the two Nobu Penthouse suites offer luxurious bi-level accommodation, soaring ceilings and internal terraces.

If 24-hour Nobu restaurant room service is your idea of heaven then consider this: here is the only place in the world where you can order up eggs Matsuhisa, the chef's take on eggs benedict, wherein the hollandaise is replaced with bonito egg sauce sprinkled with salmon roe, served on a toasted bun. Taking exclusivity a step further, there are items on the in-room dining menu that aren't available in the restaurant, including the High Roller Bento Box (US$220), filled with lobster shichimi, Wagyu steak with truffles, foie gras rice, and spinach dry miso with king crab. The Caesars Palace Nobu restaurant, meanwhile, at 12,775 sq ft, is the largest of its kind. Whether sitting at a teppanyaki table, perched at the sushi bar, hanging with celebrities in the private dining zone or just relaxing in the 327-seat lounge and bar, you've unparalleled opportunities to sample his multi-course menus in sublime sophistication.

At Nobu's Qua spa, located within the Caesars Palace spa compound, a facial treatment utilising the latest trend in aesthetic medicine, carboxitherapy - which employs carbon dioxide to combat signs of ageing - will leave you US$400 and years lighter. Nobu Hotel's celebrated mixologist, Marcus Voglrieder, may have had a hand in selecting the contents of the mini-bar but beware, it's touch sensitive. Merely lift a bottle from the fridge and it'll end up on your bill.