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  • Dec 22, 2014
  • Updated: 11:53am

Resistance to malaria drugs spreading in Southeast Asia

Experts warn resistance to current drugs used to treat malaria is growing and alternatives are not available

PUBLISHED : Wednesday, 13 November, 2013, 3:19pm
UPDATED : Wednesday, 13 November, 2013, 3:20pm

International experts raised the alarm on Tuesday over the spread of drug-resistant malaria in several Southeast Asian countries, saying it endangers major global gains in fighting the mosquito-borne disease that kills more than 600,000 people each year.

While the disease wreaks its heaviest toll in Africa, it’s in nations along the Mekong River where the most serious threat to treating it has emerged.

The availability of therapies using the drug artemisinin has helped cut global malaria deaths by a quarter in the past decade. But over the same period, resistance to the drug emerged on Thailand’s borders with Myanmar and Cambodia and has spread. It has been detected in southern Vietnam and probably exists in southern Laos, said Professor Nick White of the Thailand-based Mahidol Oxford Tropical Medicine Research Unit.

White, a leading authority on the subject, said that while there’s no confirmed evidence of resistance in Africa, there’s plenty of risk of transmission by air travellers from affected countries, such as construction labourers, aid workers or soldiers serving on peacekeeping missions.

“We have to take a radical approach to this. It’s like a cancer that’s spreading and we have to take it out now,” White told a conference at the Centre for Strategic and International Studies think tank in Washington. No alternative anti-malarial drug is on the horizon, he said.

“Once it reaches a higher level of resistance where the drugs don’t work, we are technically stuffed.”
Professor Nick White

The UN World Health Organisation, or WHO, is also warning that what seems to be a localised threat could easily get out of control and have serious implications for global health.

Mosquitoes have developed resistance to anti-malarial drugs before.

It happened with the drug chloroquine, which helped eliminate malaria from Europe, North America, the Caribbean and parts of Asia and South-Central America during the 1950s. Resistance first began appearing on the Thai-Cambodia border, and by the early 1990s it was virtually useless as an anti-malarial in much of the world.

Resistance to artemisinin is caused by various factors, such as use of substandard or counterfeit drugs, or prescribing artemisinin on its own rather than in combination with another longer-acting drug to ensure that all malaria-carrying parasites in a patient’s bloodstream are killed off.

Scientists have been working for decades to develop a malaria vaccine, but none is yet available.

Nowhere are the challenges to countering drug resistance greater than in Myanmar, which accounts for most of malaria deaths in the Mekong region, according to a report for the conference written by Dr Christopher Daniel, a former commander of the US Naval Medical Research Centre.

Myanmar’s public health system is ill-equipped to cope, although once-paltry government spending on it has increased significantly under the quasi-civilian administration that took power in 2011.

Dr Myat Phone Kyaw, assistant director of the Myanmar Medical Research Centre, said malaria drug resistance first emerged in the country’s east where migrant workers cross between Myanmar and Thailand, and is assumed to have spread to other regions. Death rates have dropped as effective treatments have become more available, but more aid and research is needed as transient workers in industries like mining and logging pose a continuing transmission risk, he said.

White insisted it is critical to prevent drug resistance creeping across Myanmar’s northwestern border into densely-populated India. “In my view, once it gets into the northeast part of India, that’s it, it’s too late; you won’t be able to stop it,” he said.

The Centre for Strategic and International Studies is advocating greater US involvement and aid for health and fighting malaria in the Mekong region, particularly in Myanmar, where Washington has been in the vanguard of increasing international aid. The think tank says that can increase America’s profile in Southeast Asia in a way that will benefit needy people and not be viewed as threatening to strategic rival, China.

But securing more funds won’t be easy at a time when Washington is cutting back on programmes assisting its own poor. The US is already a major contributor to international anti-malaria efforts, and in Myanmar, is promising US$20 million per year in health assistance under its recently resumed bilateral aid programme.

White said the problem was less a lack of funds, more than in countries having the will to take quick action to fight a disease that hits the rural poor, which have less of a political voice than urban populations.

He said infection rates have been dropping but the disease needs to be wiped out entirely or it could be distilled to the most resistant parasites and infection rates will rise again. “Once it reaches a higher level of resistance where the drugs don’t work, we are technically stuffed,” White warned.



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