“There is no more doubt that our president is a murderer and sociopathic serial killer,” De Lima told reporters, as she called on cabinet to declare him unfit to lead, and asked ordinary Filipinos to voice their opposition to his rule.

De Lima said the constitution allowed for a majority in his cabinet to force him to step down by ruling that he was mentally incapacitated, and urged it to do so. If the cabinet members did not, De Lima referred to the mass uprising that ended the “iron fist” of Marcos’s dictatorship in 1986.

“Now the time has come again for us to be brave and stand up to another criminal dictator and his evil regime,” De Lima said.

De Lima, 57, her supporters and rights groups have said the charges against her are manufactured to silence her as well as intimidate other people who may want to speak out against him.

She could be detained anytime, although the courts hearing the cases must issue an arrest warrant.

When asked about De Lima’s comments, presidential spokesman Ernesto Abella simply described them as “colourful language” and pointed out that Duterte would allow public demonstrations against him.

He immediately launched the crackdown after taking office in June and police have reported killing 2,555 drug suspects since then, with about 4,000 other people murdered in unexplained circumstances. Amnesty International has warned police actions in the drug war may amount to crimes against humanity.

But Duterte remains popular with many Filipinos, who see him as the strongman needed to fight drugs and corruption, and there is little expectation of a popular uprising against him in the near future.