Half the lanes of a 300-metre section of Ma Tau Wai Road in Kowloon City will be closed from next month while an underground station is built for the Sha Tin to Central rail link.
The MTR said two to three lanes would be closed at a time during the four-year, three-stage construction of the 320-metre station 30 metres below the surface.
The Highways Department said the closures would have little impact on traffic in the area, although some bus stops would be moved.
The station is part of the line's Kowloon City section, which is among the first parts of the HK$80 billion line to be built. The line will run from Tai Wai to Admiralty via To Kwa Wan and Hung Hom.
Project general manager Philco Wong said the closure of the road section between Chi Kiang Street and Sheung Heung Road would begin early next month if preliminary work went smoothly.
"It's a populated area, and we need to insert reinforcement frames underground so that the construction will not affect buildings nearby," he said. "It involves big machines and could take longer than usual."
Wong said the routes and frequency of 28 bus and seven minibus routes would not be affected, but all 23 bus stops and all minibus stops would be moved away from the affected area.
He appealed to drivers to take alternative routes when the project was under way.
Highways Department chief engineer for railway development Yeung Kong-sang said additional traffic lights and electronic signs giving the latest traffic information from 7am to midnight would help reduce the impact on vehicle flow.