Vitamin E can slow progression of Alzheimer's, study suggests

Experiment shows high doses seem to delay the loss of skills that dementia patients suffer

PUBLISHED : Wednesday, 01 January, 2014, 11:01pm
UPDATED : Thursday, 02 January, 2014, 2:39am

Researchers say vitamin E might slow the progression of mild-to-moderate Alzheimer's disease - the first time any treatment has been shown to alter the course of dementia at that stage.

In a study of more than 600 older veterans, high doses of the vitamin delayed the decline in daily living skills, such as making meals, getting dressed and holding a conversation, by about six months over a two-year period.

The benefit was equivalent to keeping one major skill that otherwise would have been lost, such as being able to bathe without help. For some people, that could mean living independently rather than needing a nursing home.

Vitamin E did not preserve thinking abilities, though, and it did no good for patients who took it with another Alzheimer's medication. But those taking vitamin E alone required less help from caregivers - about two fewer hours each day than some others in the study.

"It's not a miracle or, obviously, a cure," said study leader Dr Maurice Dysken of the Minneapolis VA Health Care System.

"The best we can do at this point is slow down the rate of progression."

The US Department of Veterans Affairs (VA) sponsored the study, published on Tuesday by the Journal of the American Medical Association.

No-one should rush out and buy vitamin E, several doctors warned. It failed to prevent healthy people from developing dementia, or to help those with mild impairment in other studies, and one suggested it might even be harmful.

Still, many experts cheered the new results after so many recent flops of once-promising drugs.

"This is truly a breakthrough paper and constitutes what we have been working towards for nearly three decades: the first truly disease-modifying intervention for Alzheimer's," said Dr Sam Gandy of Mount Sinai School of Medicine in New York. "I am very enthusiastic about the results."

About 35 million people worldwide have dementia, and Alzheimer's is the most common type. There is no cure and current medicines just temporarily ease symptoms.

Researchers do not know how vitamin E might help, but it is an antioxidant, like those found in red wine, grapes and some teas. Antioxidants help protect cells from damage that can contribute to other diseases, says the US Office on Dietary Supplements.

Many foods contain vitamin E, such as nuts, seeds, grains, leafy greens and vegetable oils. There are many forms, and the study tested a synthetic version of one - alpha-tocopherol - at a pharmaceutical grade and strength, 2,000 international units a day.

Years ago, another study found that the same form and dose helped people with more advanced Alzheimer's, and many were prescribed it. But vitamin E fell out of favour after a 2005 analysis of many studies found that those taking more than 400 units a day were more likely to die of any cause.

The new study involved 613 veterans, nearly all male, 79 years old on average, with mild to moderate Alzheimer's, at 14 VA centres. All were already taking Aricept, Razadyne or Exelon - widely used dementia medicines.

Participants were placed in four groups and given either vitamin E, another dementia medicine called memantine (its brand name is Namenda), both pills or dummy pills.

After a little more than two years of follow-up, those on vitamin E alone had a 19 percent lower annual rate of decline in daily living skills compared to the placebo group. Memantine made no difference, and vitamin E did not affect tests of thinking skills.

"It's a subtle effect but it's probably real," Dr Ron Petersen, the Mayo Clinic's Alzheimer's research chief, said of the benefit to daily living from vitamin E. "That has to be weighed against the potential risks" seen in earlier studies, he said.



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