South Africa at risk of spreading drug-resistant strain of TB

Lack of hospital bed space cited as one reason why sufferers pose danger to wider community

PUBLISHED : Friday, 17 January, 2014, 10:39pm
UPDATED : Friday, 17 January, 2014, 10:39pm

Patients with contagious and highly drug-resistant tuberculosis (TB) are being routinely discharged from hospitals across South Africa, exposing others in their communities to potentially deadly infections, researchers said yesterday.

In a study in the medical journal The Lancet, they said the patients, with strains of TB known as extensively drug resistant (XDR) and totally drug resistant (TDR) TB, have exhausted all available treatment options and are sent home.

"These patients can survive for months or even years and are contributing to the community-based spread of XDR-TB," said Keertan Dheda, who led the study at the University of Cape Town's department of medicine.

Tuberculosis infects the lungs and can spread through coughing and sneezing. In recent years, drug-resistant strains have spread around the world, batting off standard antibiotics and posing an increasingly urgent public health threat.

The World Health Organisation estimates that in Eastern Europe, Asia and South Africa, 450,000 people have MDR-TB, and around half of these will fail to respond to existing treatments.

Dheda's team followed 107 patients with XDR-TB from three provinces in South Africa between March 2008 and August 2012 to establish their fate.

They also took samples from 56 patients and tested them to find out which and how many of 10 first- and second-line anti-TB drugs they were susceptible to.

Despite being treated intensively with an average of eight anti-tuberculosis drugs, many of the patients fared poorly, with high rates of treatment failure and death. Five years after treatment initiation, only 12 of the patients had favourable outcomes and 74 per cent had died.

The researchers found that almost two-thirds of the tested patients had resistance to at least eight drugs, and there was one case of totally drug-resistant TB that was not susceptible to any of the 10 drugs tested.

More worrisome, Dheda said, was that of the XDR-TB patients discharged into the general community, some 42 per cent had failed to get better on treatment and were testing positive for active TB, and of these almost a third were at high risk of transmitting the disease. The patients also survived in the community for an average of 20 months - plenty of time to infect others.

"Alarmingly, we have shown for the first time that ... treatment failure and discharge of such patients into the wider community is occurring systematically on a country-wide level in South Africa," Dheda said.

Dheda said the reason many TB patients are being sent away from hospitals appeared to be lack of bed space.