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World’s first miniature dialysis machine has saved eight babies, say Italian scientists

Scientists raise money to build equipment, which has now helped eight babies survive

PUBLISHED : Friday, 23 May, 2014, 10:03pm
UPDATED : Friday, 23 May, 2014, 10:03pm
 

The world's first miniaturised kidney dialysis machine has saved the lives of eight babies in nine months, the Italian scientists who raised the money to build it said yesterday.

Until now, babies with kidney failure were treated with machines built for adults.

The machines have smaller filters and other imprecise adaptations that tend to withdraw too much or too little of the waste fluid building up in the body.

"Incredible, but true," said Claudio Ronco from the San Bortolo Hospital's renal research institute in Vicenza. "It's like using a tool for a car to fix a watch."

Yet companies have been loath to invest in baby-targeted machines as they are not profitable enough, he added.

"The number of infants around the world that suffer from this disorder is very small and therefore there is no point for a company to invest in technology."

So Ronco and colleagues launched a fundraising programme, hosting sports games and concerts and collecting €300,000 (HK$3.2 million) to build a prototype.

This attracted help from two Italian manufacturers, and so the child-friendly machine dubbed CARPEDIEM (Cardio-Renal Paediatric Dialysis Emergency Machine) was born.

The first beneficiary, a girl with multiple organ failure weighing just 2.9kg, was treated in August last year.

"The baby was almost dead," Ronco said. "This baby could not be treated with any other treatment.

"When the baby was discharged from hospital we really had the impression that we had done something very good."

The girl had 25 days of dialysis and was sent home after 50 days with her organ function restored.

Nine other babies have since been treated in Europe, of whom seven survived, said Ronco.

This was an "incredible" percentage given the historical mortality rate of up to 90 per cent, he explained.

"This technology has the potential to revolutionise the treatment of infants with acute kidney injury," said a statement from The Lancet medical journal, which published the study yesterday.

It can be used on newborns and children up to 10kg, can handle smaller volumes of fluid much more accurately, and allows the use of a much smaller catheter.

About 18 per cent of infants with low birthweight and about 20 per cent of children admitted to intensive care are estimated to suffer from acute kidney injury, according to the statement.

In a comment on the study, Benjamin Laskin, of The Children's Hospital of Philadelphia, and Bethany Foster, from Montreal's Children's Hospital, said the first patient's survival was "an outcome that would have been less likely just several years ago".

"The smile of the baby when she came to visit me three days ago - that smile was worth 40 years of medicine," said Ronco.

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