Suat Gencer, a florist working nearby, said he heard four shots and then ran to the embassy to see what had happened.

“I saw a man who had been shot in the leg. I didn’t see a knife but other witnesses said he had a knife and he would set a bomb off,” he told AFP at the scene.

Large numbers of police vehicles were at the scene and the local road was closed, an AFP correspondent said, while news channel CNN-Turk reported that a suspicious package was being investigated. Israel’s foreign ministry said the assailant was shot by a local guard and that all its embassy staff were safe.

“The assailant was wounded in the foot. We don’t know if he was attacking police officers or the embassy itself,” foreign ministry spokesman Emmanuel Nahshon said in a statement.

He added that the man reached the “outer perimeter” of the embassy and investigations were ongoing.

The incident came with foreign missions in Turkey on a state of high alert following a spate of attacks across the country this year blamed on jihadists and Kurdish militants. The British embassy in the Turkish capital Ankara was closed on Friday over security concerns while the German embassy offered only limited services.

Three months ago, Turkey and Israel signed a deal to restore their ties which hit an all-time low after the 2010 raid by Israeli commandos on a Gaza-bound Turkish aid ship that left 10 Turks dead.

Under the deal, they are to begin the process of exchanging ambassadors to fully restore their diplomatic ties, although this has yet to formally take place.

Despite the crisis, the Israeli embassy in Ankara and consulate in Istanbul have carried on working in the last years, under heavy security.

Israel had already offered compensation and an apology over the raid, but with the agreement it also eased the naval blockade on the Hamas-controlled Gaza Strip, allowing Ankara to deliver humanitarian aid to Palestinians there.

Turkey’s NTV television said employees of the embassy took refuge in a shelter during the incident on Wednesday. The health condition of the attacker was not clear but the Hurriyet daily said he had been detained by police, showing a picture of him sitting on the road with his hands tied behind his back.

It reported that he had shouted “I will change the Middle East!” when advancing on the embassy building.

Three Israelis and an Iranian were killed in March in a bombing in central Istanbul blamed on Islamic State (IS) jihadists. Israel subsequently upgraded its security advice for Turkey, encouraging citizens to leave. Israel was quick to give its support to the Turkish government in the aftermath of a July 15 coup bid, condemning it while repeating its faith in the reconciliation process.

Turkey appears to be moving back to its previous “zero problems with neighbours” foreign policy after the country also normalised relations with Russia damaged after Turkey shot down a Russian jet in November last year.

Turkey’s Prime Minister Binali Yildirim has also indicated interest in improving relations with Egypt – damaged after the ousting of pro-Ankara president Mohamed Morsi – and even Syria amid the over five year civil war.