Darren Fletcher is set to continue his return to full fitness with his first competitive start for Manchester United in 10 months when Newcastle visit Old Trafford tonight for their League Cup third-round clash.
The Scotland international midfielder made his first appearance for United as a second-half substitute against Galatasaray last week since his chronic bowel condition left his football career hanging in the balance.
Now he is set to make his first start since November last year after spending the end of last season helping to coach United's reserve side as he battled the illness before working during the summer to make his comeback.
Fletcher, 28, has had to change his diet and adapt his lifestyle to overcome the ulcerative colitis condition and Ferguson is delighted to be able to include him in his starting line-up as he prepares to make a host of changes from their 2-1 win over Liverpool.
If the Scot comes through the game unscathed he could be in line for his Premier League return against Tottenham on Saturday.
Ferguson said: "Fletcher will certainly play against Newcastle and that is the perfect game for him to start back. Then we have the game against Tottenham and he could be involved in that.
"It depends on how he does on Wednesday. It will be his first 90 minutes since 10 months out. It's a big one for him. He is handling the condition at the moment, as we saw the other night he is looking fine.
"It is a matter of hoping the condition stays dormant and he is handling his diet well. Hopefully he gets that break."
Ferguson will make a number of changes for the League Cup as he usually does in the early stages and Alexander Buttner, Anderson and Tom Cleverley could all feature, having not played a part in the Liverpool game despite being on the bench.
Meanwhile, United defender Rio Ferdinand expressed his relief at getting the game against Liverpool out of the way after United stuttered to victory over 10 men on an emotional afternoon when Hillsborough was remembered.
He said: "With the occasion and the emotions involved, we just wanted to come here, get the job done and get out with the three points. We have done that so we are well pleased.
"You can get really involved and sometimes the emotion of the occasion can affect you, but they dealt with it fantastically."
Newcastle may field a strong side with Fabricio Coloccini and Cheick Tiote set to get minutes under their belts while Shola Ameobi, Dan Gosling and Sylvain Marveaux could also feature.
The Magpies have not won at Old Trafford since 1972. However, manager Alan Pardew is going to give the competition a real go despite knowing it will be a tough test against Ferguson's side even if the hosts field a weakened side.
Pardew said: "Of course you want to enjoy going there. We are going to have to make sure we can get game time out of the players that will need it.
"Colo could play, Cheick definitely needs a game, he was rusty [against Norwich], so I will have a word with the staff and hopefully we'll get a result there."