Peyton Manning did not need to match his record-equalling seven touchdown passes from the Broncos' season-opening victory. The team also had Trindon Holliday's spectacular 81-yard punt return for a touchdown, the first such score in the league this season.

The older Manning is 3-0 in the NFL against his sibling, with the other two victories coming when Peyton was with the Colts.

"It's a strange situation, strange circumstances," Peyton said. "It's a good team win, but it's a unique situation. You can't ask too many people for advice on it.

"I think both of us are glad that it's over with. Post-season is one thing, but I don't think I'll make it to the next regular season (meeting in four years). I think this'll be the end of it. So I'll be happy about that. And the family will. For Eli and I, it'll be just as easy."

Peyton did not need to match his record-tying seven touchdown passes from the Broncos' season-opening victory. Not with the Giants (0-2) being charitable again with four more turnovers after they had six in last week's loss.

"We'll see what kind of team we have and what kind of fight we have," Giants guard Chris Snee said.

At Seattle, Marshawn Lynch ran for two scores and added a seven-yard TD catch in the second half as the Seahawks flustered Colin Kaepernick into his worst passing game as a starter in a 29-3 win over the 49ers.

The game was delayed 60 minutes by thunderstorms late in the first quarter. The highly anticipated NFC West showdown was sloppy as opposed to sensational, but Lynch more than did his part.

Lynch finished with 135 total yards, including 98 yards rushing, to make up for quarterback Russell Wilson hitting on just two of his first 10 throws with Seattle's receivers struggling to get open. His scoring run on the first drive of the second half gave the Seahawks a 12-0 lead and his TD catch pushed the advantage to 19-3 early in the fourth quarter.

At Green Bay, Wisconsin, Aaron Rodgers threw for a career-high 480 yards and four touchdowns as the Packers used a big first half to win their home opener against the Washington Redskins 39-20.

Redskins quarterback Robert Griffin III threw for 320 yards and three second-half touchdowns. Pierre Garcon had 143 yards receiving and a touchdown.

Philadelphia's Philip Rivers threw three touchdown passes to Eddie Royal, and Nick Novak kicked a 46-yard field goal with seven seconds left, spoiling Chip Kelly's home debut in the Chargers' 33-30 win over the Eagles.

In other games, the Arizona Cardinals had a 25-21 home win over the Detroit Lions, the Baltimore Ravens were 14-6 winners over the Cleveland Browns and the Oakland Raiders downed the Jacksonville Jaguars 19-9.