"I enjoyed it. We were playing a good team and felt really motivated to score points - touchdowns and not field goals - and we did that," Manning said.

Demaryius Thomas and Wes Welker had two touchdown receptions each, while Trindon Holliday scored with a 105-yard kick-off return.

Not for the first time this season, Denver ran away with the game in the third quarter with Manning throwing three touchdowns in that period. They have scored 62 points in the third term this season.

After struggling for three weeks to get into the groove with his new receivers, Tom Brady threw for 316 yards and two touchdowns in his best outing of the season for the unbeaten New England Patriots, who held off a furious Atlanta comeback to beat the Falcons 30-23.

New England improved to 4-0 for the first time since their near-perfect season in 2007.

"We slugged it out," Brady said. "We came to Atlanta, which is a tough place to play and they've got a very good team. It's nice to win and be 4-0."

The Seattle Seahawks also extended their winning start to a franchise record four games after a 23-20 comeback victory in overtime at the Houston Texans, while the New York Giants suffered a fourth straight loss with a miserable 31-7 defeat at Kansas City.

The Seahawks' impressive start to the season looked in danger when they trailed 20-3 in Houston but, helped by some poor choices by Texans quarterback Matt Schaub, Seattle clawed their way back.

Two touchdowns and a pair of field goals in the second quarter had put Houston in charge, but Seahawks quarterback Russell Wilson turned on the style in the fourth and they levelled with less than three minutes to go.

Houston could not score on two possessions in overtime and Steven Hauschka's 45-yard field goal secured the victory for the Seahawks.

"This was an extraordinary day," said Seahawks head coach Pete Carroll, who added that his team had rediscovered their personality in the fourth quarter.

"We just wanted to be who we were capable of being and we weren't doing that for a while," he said after his team achieved the best start since entering the league in 1976.

New York Giants head coach Tom Coughlin was in a vastly different mood after his team's fourth straight loss, describing their second-half performance as a "debacle".

The Chiefs, off to a 4-0 start under former Philadelphia head coach Andy Reid, ran away with the game in the fourth quarter.

Chiefs quarterback Alex Smith threw for 288 yards and three touchdowns, while his counterpart Eli Manning was sacked three times and threw one interception.

After a scoreless first quarter, the Chiefs got in front when Sean McGrath collected a five-yard touchdown pass from Smith, but the Giants responded with Manning finding Victor Cruz for a 69-yard touchdown.

But the Giants, in a season with the Super Bowl in their home stadium, look to have problems in all areas and Coughlin said he was hoping for a reaction from his veteran players.

"I'm depending heavily on the leadership and character of guys in the locker room … we will have to pick ourselves up and try to improve on the second-half debacle here," he said.

On a bad day for New York teams, the Jets were beaten 38-12 by the Tennessee Titans.

The defending Super Bowl champions, the Baltimore Ravens, also had a tough day with quarterback Joe Flacco throwing five interceptions in a 23-20 loss at Buffalo.

Buffalo rookie linebacker Kiko Alonso had two interceptions against Baltimore, the second making sure of the win with 57 seconds left in Orchard Park.

With Aaron Williams also grabbing two picks it was a poor performance from Flacco, the Super Bowl most valuable player last season, who will take little from his two touchdown throws and 347 yards passing.

Robert Griffin gained his first win of the season, though, as Washington overcame the Oakland Raiders with 24 consecutive points in a 24-14 victory.