Bayern Munich will set a new Bundesliga record if they claim their eighth straight win since the season began at Fortuna Dusseldorf today, while champions Borussia Dortmund host neighbours Schalke.
Dusseldorf, meanwhile, are looking for their first home victory this season having claimed both their league wins so far on the road.
A Bayern victory would also be coach Jupp Heynckes' 300th in the Bundesliga.
Bayern will be without winger Arjen Robben for the foreseeable future with his injured thigh muscle injury needing more time having struggled since their 3-0 win over Wolfsburg at the end of September.
"It's nothing serious, but we cannot say exactly when the pain will be resolved," Bayern's director of sport Matthias Sammer said.
"We are doing him no favours to constantly discuss what day he comes back."
Bayern defender Jerome Boateng has said the Bavarians' Germany stars are eager to get back to Bundesliga business to erase the memories of Germany's shock 4-4 draw with Sweden.
Munich had seven players on the pitch for Germany in Berlin when Sweden began their fightback from 4-0 down on Tuesday to score four goals in 30 minutes and stun their hosts by sealing a draw in their important World Cup qualifier.
"We are back at Bayern, the national team is behind me now," he said as Bayern enjoy a five-point lead at the top of the table.
"It is important that we get back into things quickly after being with the national team and find our rhythm again.
"We want to remain on top and far ahead of the other teams."
Dortmund, fourth in the league, take on third-placed Schalke at home today with a nine-point gap to close behind Bayern.
"Schalke have brought some calm back into the club and they have a good team. They have really improved in quality and they are serious contenders for the title," said Dortmund captain Sebastian Kehl.
"Overall, our team has more potential and I hope we show it on Saturday."