Only Barca’s superior head-to-head record separates them from their Champions League conquerers Atletico Madrid at the top of the table with Real Madrid lurking just a point further back after a run of seven straight league wins.

All three face tough tests on a Wednesday evening of action that will go a long way to settling the title with the fixture list for all three favourable in the final four games.

Barca are up first as they travel to Galicia in a desperate search to snap their worst run of league defeats in 13 years.

Enrique and key defender Gerard Pique insisted Barca can and will win the league if they play like they did against Valencia on Sunday despite slipping to a 2-1 defeat thanks to a mixture of bad luck, poor finishing and a brilliant goalkeeping display by Diego Alves.

“If there is a team capable of doing it and much more given what they have done, it is this Barca,” said Luis Enrique.

“We don’t have any margin for error, but I prefer to lose like this than win playing badly,” added Pique.

“Football is like this, sometimes it is marvellous, sometimes it is so cruel.”

However, Pique’s absence at the heart of Barca’s defence through suspension will be a huge loss for Enrique with Marc Bartra expected to cover in the absence of Jeremy Mathieu and Thomas Vermaelen.

Atletico face a daunting trip to Athletic Bilbao with the Basques still eyeing Champions League football next season having moved to within six points of fourth-placed Villarreal at the weekend.

A 2-1 victory at San Mames propelled Atletico towards the title two years ago and Diego Simeone’s men could be further boosted by the absence of Bilbao’s two top scorers this season in Aritz Aduriz and Inaki Williams through injury.

“We have the possibility to play an important game in Bilbao and continue competing in the four games left afterwards,” said Simeone when quizzed on Atletico’s title chances.

“It will be difficult, but we have to do what the schedule demands of us and that is win, win and win again.”

Atletico will be forced into at least one change as captain Gabi is suspended, but Fernando Torres will start alongside 29-goal Antoine Griezmann up front after scoring in four consecutive games for the first time since he was at Liverpool in 2010.

Real will have the advantage of knowing what Barca and Atletico have done when they kick-off in the late game at home to Villarreal.

Zinedine Zidane could afford the luxury of resting the likes of Sergio Ramos, Casemiro and Luka Modric for Saturday’s 5-1 rout of Getafe on Saturday with all three expected to return.

The much-criticised Danilo is also expected to start at right back with Dani Carvajal a major injury doubt.