FACED with increasing restrictions and undeniable medical evidence, tobacco companies are turning away from traditional Western markets to less regulated developing economies.
And the number one target for expansion is China - home to an estimated 300 million smokers, one-third of the global market, which has in the past been supplied by the world's largest single government tobacco monopoly.
The rewards in China are huge, although the tobacco companies say they have not attempted to calculate the potential revenues.
But they could be looking at sales of 1,204 billion cigarettes a year. Not surprisingly, the biggest tobacco company in the world, Philip Morris, is desperate for a foothold in the Chinese market.
Last year the company moved a step closer with the signing of a joint venture with the China National Tobacco Corporation to manufacture Marlboro cigarettes in China. It is the first such deal struck with an international tobacco company.
The Asian manufacturing base of Philip Morris is growing - last year they began building a leaf processing plant in Malaysia, produced Marlboro cigarettes for the first time in Vietnam and unveiled plans to build a cigarette factory in Kazakhstan.
The agreement is multi-faceted with room for further concessions and will use China's home-grown tobacco.