Heavy losses could drive several leading insurance companies to pull out of the employees' compensation market, driving up policy costs for employers.
KPMG partner Steve Roder said it was likely some substantial players would stop selling employees' compensation insurance from next year.
Intense competition has driven down prices in the sector, causing continued losses for participants.
'It is inevitable some big players will decide to leave the local employees' compensation market as they have continued to suffer losses for the past few years,' said Mr Roder, who heads KPMG's Asian insurance division.
Under a scheme introduced in the mid-1980s, employers are required to buy insurance to cover all staff in case of workplace injuries.
The scheme covers Hong Kong's three-million-strong working population - a large and potentially lucrative market that attracted 94 general insurers.