Top-of-the-table clash against Arsenal will determine London bragging rights - and if the millions have been well spent The top two clash in the English Premiership tonight with Chelsea putting their new-found leadership on the line at Arsenal and, just as crucially, seeking to redress the balance of power in London. Chelsea went top on goal difference when they drew their game in hand 0-0 at Birmingham in midweek, but the Arsenal clash will be another acid test of their championship challenge. Arsenal have dominated affairs in the capital in recent years - disproving the notion that a London team couldn't win the title because of the amount of derby matches they had to play - but Chelsea are still struggling to overcome the derby factor. While Arsenal have lost only two games against fellow London teams in the past three seasons (28 matches), Chelsea have lost nine times in the same period - conceding 13 points to Arsenal in London alone last season and seven the season before. And Arsenal have held the upper hand in clashes with Chelsea, gaining 12 wins and seven draws in 22 Premiership meetings. Arsenal have won their last nine home London derbies - in fact 12 of their last 14 - and Chelsea's only win in their last 18 visits to Highbury came against weakened opposition in the League Cup five years ago. Those are statistics which Chelsea must put right if they are to win the title and they made a good start with last month's 4-2 home win over Spurs. Their momentum has slowed since then, however, while Arsenal have recovered well from their shock 3-0 home defeat by Inter Milan in the Champions League - drawing at Manchester United and winning at Liverpool. Chelsea clearly have the quality to get a result, but form and history point to a narrow Arsenal win. Tonight's first live match - Leeds United v Manchester United - would have been a big attraction in recent seasons but has lost some of its importance due to Leeds' dramatic decline. The rivalry remains intense, however, and 10 of their last 13 meetings have been settled by a single goal, so the visitors are unlikely to have an easy time despite Leeds' leaky defence. Even so, it is hard to see past a win for the champions. Plenty of local scores will be settled this weekend, with Middlesbrough hosting Newcastle, Manchester City facing Bolton and Birmingham taking on Aston Villa. Only the derby factor could help Bolton and Villa, who both have poor away records and face in-form rivals, while the Tyne-Tees derby looks too close to call. Tonight's other live match sees Portsmouth play host to Liverpool, where the biggest question is whether the home team's good start was a true indication of their ability to handle the rise to the Premiership. Portsmouth were unbeaten in their first five games, with two home wins and three away draws, but their form since the end of August has been the worst in the league. Consequently they are a big price to beat Liverpool, who have done well away but have yet to take a single point from a team in the top half. The evidence is conflicting, but Portsmouth's price is too good to miss. Tonight's final Premiership game sees Fulham take on bottom club Wolves. That looks a home banker, while Everton can justify the same tag at bigger odds in tomorrow's late live game against Southampton. Leicester v Spurs and Blackburn v Charlton are not the most exciting TV clashes and do not appeal as betting options either. The TV line-up from the rest of Europe is first-class - Celta Vigo v Real Madrid and Barcelona v Deportivo (as well as the Seville derby) in Spain and Roma v Parma and AC Milan v Lazio in Italy. Real Madrid, as usual, are too short against Celta, whose home record deserves plenty of respect despite their slow start to the season. Celta may not be showing enough to merit a win bet, but they cannot be dismissed easily. Barcelona and Deportivo are both priced at 2.45 in the Jockey Club's early show - a big price for Barca on their own patch but not surprising given their disappointing displays this season. It is hard to justify a bet on the home side, though they could improve if coach Frank Rijkaard decides to leave Javier Saviola in the forward line, and Deportivo are decent value for the win. Another fairly sound away bet in Spain is Real Sociedad at Albacete, who have adopted a very negative approach against the big teams. The biggest risk is whether Sociedad, a fairly low-scoring side, will do enough to win. AC Milan, especially, and Roma are fancied for the big Italian games but it is hard to find any value there this week. Inter are evens to win at Brescia but their form is too in-and-out to make them a reliable bet. Bayern Munich look a fairly safe selection at struggling Borussia Monchengladbach, but the most appealing bet in Germany is in the big match, with Werder Bremen fancied to end Stuttgart's long run of clean sheets. Stuttgart have not played away to a team of Werder's quality this season - except, perhaps, Glasgow Rangers, who beat them 2-1 in the Champions League - and the Bundesliga leaders look overpriced. Talking of Rangers, they host Manchester United in the Champions League in midweek and it should be a cracker. Rangers deservedly beat Stuttgart, who then defeated United 2-1 in Germany, so there is all to play for in Group E. United are unlikely to settle for a draw and could well be a decent-value win bet on a tricky list. Overall this is the most interesting round of matches so far in the Champions League, with Chelsea at home to Lazio, Juventus hosting Real Sociedad and Monaco travelling to Deportivo. Three home wins are the pick there, with Chelsea expected to field their best side against unimpressive Lazio and make amends for their 2-0 home defeat by Besiktas last time. Arsenal, even more than Chelsea, will struggle to progress if they don't win this week and that makes them a decent bet at Dynamo Kiev. Arsenal's recent away form is respectable even in Europe (three wins and two draws in their last seven) and they can be guaranteed to be playing for all three points. (always a key consideration for punters in the cagey group stages). Best homes: Werder Bremen, Arsenal, Fulham (v Wolves), Everton, AC Milan. Best aways: Bayern Munich (v Monchengladbach), Real Sociedad (v Albacete), Arsenal. High goals: Wolfsburg v Rostock, Ancona v Juventus, Barcelona v Deportivo. Low goals: Middlesbrough v Newcastle, Birmingham v Aston Villa, Chievo v Sampdoria.