The best way to handle career unrest is to work with what you already have. But some sources of job dissatisfaction are insurmountable. Here are four signs that it is time for a change: The culture of the organisation has changed dramatically and no longer matches your own values and style. If you constantly experience frustration about the way your company does things, you risk long-term stress and even ill health. As it is unlikely you will be able to change the company's culture, this is one situation where it is definitely time to move on. You cannot get on with your boss. First, try to build a more trusting and open relationship. But if you are working for someone who is unreasonable, unavailable or untrustworthy, it is time to look for a better supervisor and a better opportunity. You have stopped learning, but the company will not support further development. If you have no idea where you are going in the company, talk to your manager and come up with a plan. If the company is uninterested in your development, they do not value you; it is time to look elsewhere. You are failing to meet performance goals and can see no way of improving. Constant underperformance will drain your energy and confidence. Ask if you have the skills and ability to do what your company expects of you, and whether it is realistic to try to meet these expectations. You may be in the wrong job - cut your losses and find a better fit.