Paediatric rheumatism can be classified into three categories: Pauciarticular: affects about 50 per cent of sufferers and involves four or fewer major joints, such as elbows, knees and ankles. Polyarticular: affects about 30 per cent of sufferers, involves five or more joints, and is more serious. Systemic: the most serious but the least common, causing inflammation of internal organs including the heart, liver, spleen and lymph nodes. Paediatric rheumatism is caused by the body's immune system attacking its own healthy cells and tissues. It can be inherited and affects more women than men. The wide and varying range of symptoms make the disease difficult to diagnose and can delay treatment, which can cause further destruction. The following symptoms may appear during flare-ups or may be chronic and continuous: Swollen, stiff and painful joints, especially when waking High fever and rash Swollen lymph nodes Inflamed eyes (detectable only by an ophthalmologist) Warm, red, inflamed joints Fatigue Decreased appetite and weight loss or slow growth.