Doctors have reminded people not to take swine flu lightly and those in high-risk groups to be vaccinated against seasonal flu. This came after five Hong Kong patients died in four days, with two of the deaths yesterday along with Macau's first fatal case reported. A 47-year-old man with leukaemia was admitted to Pamela Youde Nethersole Eastern Hospital last Thursday with fever and shortness of breath. He was confirmed to have swine flu the next day and given Tamiflu and antibiotics. His condition continued to deteriorate and he died yesterday afternoon. His case has been referred to the coroner. In another case, a 59-year-old chronic disease patient developed flu symptoms on August 15. He attended Yan Chai Hospital's emergency room and was admitted to the isolation unit on August 20, where he received Tamiflu and antibiotics. His condition deteriorated and he was transferred to intensive care the next day, where he tested positive for swine flu. He died yesterday. Meanwhile, Macau reported its first death - a 40-year-old woman with no history of chronic illness. The woman, who was an administrator at the Grand Lisboa Casino, developed flu symptoms on August 10. Her condition deteriorated and she was admitted to Kiang Wu Hospital on August 16. Two days later, she was transferred to Hospital Conde de Sao Januario in critical condition. Hong Kong Medical Association president Dr Tse Hung-hing said the fatalities had been expected and he warned the public it was wrong to take the disease lightly. 'It's not a light disease. We should never be at ease against it,' he said. The doctor added that there would be more fatalities, especially in the winter. Chinese University respiratory medicine professor David Hui Shu-cheong said there was no reason to panic as the recent deaths in Hong Kong were all high-risk patients who either smoked or had chronic diseases. He expected more flu infections this winter, so high-risk groups, including the elderly, young children and those with lower immunity, should be vaccinated against seasonal flu by November. If the swine flu vaccine did not yield any side effects in Europe and North America, Hui said high-risk groups should also be vaccinated when it became available to Hong Kong. Hong Kong has reported nine swine-flu related deaths. A total of 321 new cases were reported yesterday, taking the total to 12,456. On Tuesday, a 50-year-old obese man died after taking Tamiflu and antibiotics. He was admitted to Alice Ho Miu Ling Nethersole Hospital on August 17 and had been in intensive care since August 19. On Monday, a 65-year-old man with history of asthma, pneumonia and heart disease died in North District Hospital. He had returned from the mainland on August 24, was confirmed with swine flu and admitted to the intensive care unit the following day. On Sunday, a 43-year-old woman smoker died. She went down with flu symptoms on August 23 and was admitted to Tuen Mun Hospital intensive care unit on August 26.