Blood test may help find early-stage pancreatic cancer, one of the deadliest forms of the disease and often diagnosed too late

US researchers genetically reprogrammed cancer cells and discovered indicators of early-stage pancreatic cancer, a disease usually diagnosed too late to treat patients; blood test derived from study could be ready for use soon

PUBLISHED : Thursday, 13 July, 2017, 1:06pm
UPDATED : Thursday, 13 July, 2017, 1:06pm

A new blood test may accurately detect pancreatic cancer in its early stages, offering new hope for people at risk of this fast-moving and often fatal disease, researchers said Wednesday.

Typically, pancreatic cancer is discovered when the tumours are too large to treat. Four in five patients die within a year of diagnosis.

More than 53,000 people in the United States are diagnosed with pancreatic cancer annually. It is the fourth leading cause of cancer death. Well-known victims of the disease include Apple founder Steve Jobs, actors Patrick Swayze and Alan Rickman, and singer Luciano Pavarotti.

A long-standing concern has been that patients with pancreatic cancer are often not diagnosed until it is too late for the best chance at effective treatment,” said study co-author Robert Vonderheide, director of the Abramson Cancer Centre at the University of Pennsylvania. “Having a biomarker test for this disease could dramatically alter the outlook for these patients.”

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Using stem cell technology to create a cell line from a patient with an advanced form of pancreatic cancer, researchers were able to turn back the clock on the progression of the disease.

In doing so, they found a pair of biomarkers – or identifiers in the blood – that picked up pancreatic cancer in human cancer cells at different stages of tumour growth.

Some more work will be needed but in general the test and concept could be applied
A spokeswoman for researchers

“Genetically reprogramming late-stage human cancer cells to a stem-cell state enabled them to force the reprogrammed cells to progress to an early cancerous state, revealing secreted blood biomarkers of early-stage disease along the way,” said a summary of the report, published in the journal Science Translational Medicine.

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One biomarker known as plasma thrombospondin-2 (THBS2), combined with a known later-stage biomarker called CA19-9, “consistently and correctly identified all stages of the cancer,” said lead author Ken Zaret, director of the Penn Institute for Regenerative Medicine.

“Notably, THBS2 concentrations combined with CA19-9 identified early stages better than any other known method.”

The test could be done with an inexpensive, commercially available protein-detection assay, researchers said.

In principle, the test could be applied right away, though researchers cautioned they want to do further work “to be absolutely certain of the cut-off values that we have for what is a significant or likely call for disease”, a spokeswoman said.

“Some more work will be needed but in general the test and concept could be applied,” she said.

A key population for the test would include people with a family history of pancreatic cancer, those with a genetic predisposition to the disease, or who had a sudden onset of diabetes after the age of 50.

Earlier this year, a separate team of researchers in the United States and China unveiled a new blood test for detecting pancreatic cancer.

That method involved finding a protein dubbed EphA2 found in pancreatic tumours, according the February report in the journal Nature Biomedical Engineering.