There’s still no HIV vaccine. Could Covid-19 jab technology – mRNA shots or modified cold virus – be the answer?
- After 40 years, HIV treatment has advanced dramatically, but there is still no sign of an effective vaccine
- Various trials have taken place without success, but there are hopes for a trial mRNA vaccine and another that uses a genetically modified cold virus
In the four decades since the first cases of what would come to be known as Aids were documented, scientists have made huge strides in HIV treatment, transforming what was once a death sentence to a manageable condition.
What we still don’t have is a vaccine that would train human immune systems to ward off the infection before it ever takes root.
Why do we need a vaccine?
Beyond ART, people at high risk of infection can now get pre-exposure prophylaxis, or PrEP, a pill taken every day that reduces the risk of infection by 99 per cent.
“But access to medication is not organised in every part of the world,” Hanneke Schuitemaker, global head of viral vaccine discovery at Johnson & Johnson’s Janssen Vaccines, said.
Even in wealthy countries, wide socio-economic and racial disparities exist in accessing these medicines, and vaccines have historically been the most effective tools to eradicate infectious diseases.
Johnson & Johnson (J&J) is currently carrying out two human efficacy trials for its HIV vaccine candidate, and initial results from one of them may come as early as the end of this year, Schuitemaker said.
Why is it so challenging?
Vaccines against Covid-19 were developed in record time and have shown remarkable levels of safety and efficacy, helping drive down caseloads in the countries fortunate enough to have wide access.
Many of these shots were developed using technologies that were previously being tried out on HIV – so why haven’t we had breakthroughs yet?
“The human immune system doesn’t self cure HIV, whereas what was very clear was the human immune system was quite capable of self curing Covid-19,” said Larry Corey, principal investigator of HVTN, a global organisation funding HIV vaccine development.
HIV also has spike-shaped proteins on its surface, which are the target of HIV vaccine development.
But while Covid-19 has tens of well known variants circulating worldwide, HIV has hundreds or thousands of variants inside each infected person, said William Schief, an immunologist leading development of an mRNA HIV vaccine at Scripps Research Institute in California.
Because it’s a retrovirus it quickly incorporates itself into its host’s DNA. An effective vaccine will need to stop the infection dead in its tracks, not just reduce the amount of virus and leave the remainder to stay with the person forever.
Where do things stand now?
Efforts to develop a vaccine have been going on for decades but have so far all ended in failure. Last year, a study called Uhambo that was taking place in South Africa and involved the only vaccine candidate ever shown to provide some protection against the virus frustratingly ended in failure.
J&J’s vaccine candidate is currently being trialled in 2,600 women in sub-Saharan Africa in the Imbokodo trial, which is expected to report results in the coming months.
It’s also being tested in around 3,800 men who have sex with men and transgender individuals across the United States, South America and Europe in the Mosaico trial.
This is followed up by directly injecting synthetic proteins in later doses.
Another promising approach is to try to generate “broadly neutralising antibodies” (bnAbs) which bind to areas of HIV that are common across its many variants.
The International Aids Vaccine Initiative and Scripps Research recently announced results from an early stage trial showing their mRNA vaccine candidate, developed with Moderna, stimulated the production of rare immune cells that create bnAbs.
Their strategy, explained Schief, is to use a sequence of shots to try to gradually educate antibody-producing B-cells. They also hope to train up another kind of white cell, known as a T-cell, to kill any cells that still get infected despite the antibodies.
Efficacy trials are still a long way off, but he’s hopeful the mRNA technology, which turn the body’s cells into vaccine factories and has proven its worth against Covid-19, can make the difference.