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LifestyleHealth & Wellness

Will you develop Alzheimer’s disease? Early signs could be detected in your eyes before symptoms arise

  • Scans of the eyes’ retinas can identify key changes in blood vessels which may provide an early sign of Alzheimer’s disease, new research shows
  • Small vessels in the retinas may also be linked to other brain diseases, including other types of Alzheimer’s disease, Parkinson’s and certain dementias

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The University of California, San Francisco team examined tiny blood vessels at the back of the eyes of elderly people with and without APOE4 gene mutations, the most prevalent genetic risk for Alzheimer’s disease. Photo: Getty Images
Anthea Rowan

Scans of the eyes’ retinas can identify key changes in blood vessels which may provide an early sign of Alzheimer’s disease, according to new research from the University of California, San Francisco (UCSF).

The retinas also offer important insights into how one of the most common genes for Alzheimer’s risk contributes to the disease, the researchers say.

That the eyes can offer a lens on our health is not news. The brain is tightly packed inside the skull, so anything extra in there – additional blood, fluid or growing tumours – increases the pressure in a relatively small space. This can lead to the eyes giving signs of a problem in the skull or even elsewhere in the body.

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For example, pressure in the brain can cause the optic nerve to swell and may indicate the presence of glaucoma, a degenerative disease that can lead to blindness. That is why it’s not unusual for optometrists to identify illness before a doctor does; they sometimes even spot brain cancers before a patient is aware anything is wrong.
A retinal photograph of a human eye taken using professional clinical diagnostic equipment. Photo: Getty Images/iStockphoto
A retinal photograph of a human eye taken using professional clinical diagnostic equipment. Photo: Getty Images/iStockphoto

“Because blood vessels in the eye have the same embryo origin, histology and structure as those in the brain, they serve as an incredibly convenient way to assess changes in the retinal blood vessels which could indicate changes in the blood vessels in the brain,” says Andy Meau, a Hong Kong-registered optometrist and director of Central Eye Care.

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