This is the first detailed account of what happened to Wu. She declined to be inter­viewed for this article, citing a pending com­plaint she’s filed with the US Equal Employment Opportunity Commission. Her story is based on interviews and docu­ments provided by 14 American colleagues and friends and records obtained through the Texas Public Information Act.

Wu graduated from medical school in Shanghai and earned her PhD in 1994 from the University of Texas School of Public Health in Houston. She joined MD Anderson while in graduate school and gained renown for creating several so-called study cohorts with data amassed from hundreds of thousands of patients in Asia and the US. The cohorts, which com­bine patient histories with personal bio­mark­ers such as DNA characteristics and treatment descriptions, outcomes and even lifestyle habits, are a gold mine for research­­ers. For example, Wu and her team showed that Mexican-Americans who sleep less than six hours a night had a higher risk of cancer than Mexican-Americans who get more sleep, and that eating charred meat such as barbecue raised the risk of kidney cancer. In 2011, Wu leapfrogged older colleagues and was named epidemiology chair, making her the top-ranked epidemiologist at the nation’s top-ranked cancer centre.

Along the way, Wu developed close ties with researchers and cancer centres in China. She was encouraged to do so by MD Anderson. The centre’s president in the early 2000s, John Mendelsohn, launched an initiative to promote international collabor­ations. In China, MD Anderson forged “sis­ter” relationships with five major cancer centres, cooperating on screening program­mes, clinical trials, and basic research studies. Dozens of ethnic Chinese faculty members at MD Anderson partici­pated, eager to visit family and friends and contri­bute their expertise to addressing China’s enormous burden of about 4.3 million new cancer cases a year. In 2015, China awarded MD Anderson its top honour for inter­national scientific coopera­tion, in a cere­mony attended by President Xi Jinping.

Wu was a model collaborator. She attend­ed Chinese medical conferences, hosted visiting Chinese professors in Houston, and published 87 research papers with co-authors from 26 Chinese institu­tions. In all, she has co-authored some 540 papers that have been cited about 23,000 times in scientific literature. (Her papers are all easily retrievable with a few clicks on MD Anderson’s website.)

“MD Anderson was very much an open door. The mission was ‘End cancer in Texas, America, and the world’,” says Oliver Bogler, the cancer centre’s senior vice-president for academic affairs from 2011 to 2018 and now chief operating officer of the ECHO Institute at the University of New Mexico.

The globalisation of science, in particu­lar basic science, has been sweeping. “Facul­­ty don’t see international borders any more,” says Adam Kuspa, dean of research at Baylor College of Medicine in Houston. “If someone in another country has a piece of the puzzle, they want to work with them.” Relationships often begin at academic conferences, gel during invited visits for symposiums or lectureships and culminate in the melding of research into scientific papers. Since 2010 the NIH has offered about US$5 million a year in grants for US-China collaborations, with 20 per cent going to cancer research, and a counterpart in China has pitched in US$3 million a year. The joint projects have produced a number of high-impact papers on cancer, according to an internal NIH review.

For Kirk Smith, a professor at the Uni­ver­sity of California at Berkeley who studies the health effects of air pollution, the bene­fits of collaboration have been surprising. He never imagined, back in the 1980s, when he started researching Chinese air pollution with Chinese scientists, that his colleag­ues would become policy­makers at home. In the past six years, Smith’s partners have push­ed through standards that have seen air pollu­tion fall by up to 42 per cent in China’s most populous areas. The results have borne fruit in the US, too. Twenty years ago scientists forecast air pollution from China, blowing across the Pacific, would cause California to exceed its clean-air standards by 2025. Now that won’t happen, says Smith, who was granted an honorary professorship at Tsinghua University this spring.

Wu’s work, like much of the academic research now in danger of being stifled, isn’t about developing patentable drugs. The mission is to reduce risk and save lives by discovering the causes of cancer. Prevention isn’t a product. It isn’t sellable. Or stealable.

Creating a climate of fear for Chinese scientists in the US benefits neither Washington nor Beijing

Suspicion of Chinese scientists at MD Anderson began to take root in 2014. The year before, a Chinese research­er at the Medical College of Wisconsin in Milwaukee had been arrested on federal charges of economic espionage; prosecu­tors said he stole three vials of a cancer drug in early-stage lab testing. (He pleaded guilty to the lesser charge of accessing a computer without authorisation and was sentenced to time served, 4½ months.) At the time, MD Anderson was pushing to commercial­ise basic research into cancer drugs; today the centre has alliances and partnerships with almost three dozen pharmaceutical makers and other private companies. Security was enhanced. Foreign guests were kept on a short leash.

The chain of events that ultimately led to Wu’s departure began in the summer of 2017, when the FBI notified the cancer centre it was investigating “the possible theft of MD Anderson research and propri­etary information”. (MD Anderson declined to speak about the FBI investigation except to say it did not report theft of intellectual property to the bureau.) A federal grand jury followed up with a subpoena for five years of emails from some MD Anderson employees. A few months later, the centre gutted its international research pro­gramme and put what was left of its collaborative-project arm under a business department. Bogler and former colleagues within the centre say the focus then shifted away from research collaborations and toward business opportunities. MD Anderson spokeswoman Brette Peyton said in an email that the centre’s global programmes haven’t changed.

In November 2017, the FBI asked for more information. This time, no subpoena followed. Instead, the cancer centre’s presi­dent, Peter Pisters – then on the job for barely a month – signed a voluntary agree­ment allowing the FBI to search the net­work accounts of what a separate document indicated were 23 employees “for any purpose […] at any time, for any length of time, and at any location”. Did all of the network accounts handed over to the FBI belong to Chinese or Chinese-American scientists? MD Anderson refuses to say.

In Wray’s telling, China’s challenge to the US today is unlike any that nation has faced. Whereas the cold war was fought by armies and governments, the contest is being waged, on China’s side, by the “whole of society”, the FBI director said, and the US needs a whole-of-society response. But what does that look like in a society with more than 5 million citizens of Chinese descent?

The FBI is telling companies, univer­si­ties, hospitals – anyone with intellectual property at stake – to take precau­tions when dealing with Chinese business partners and employees who might be what Wray calls “non-traditional” information collectors. US Department of Justice officials are doing roadshows to brief local governments, com­panies and journalists about China’s perfidy. Visas for Chinese students and researchers are being curtail­ed, and more Chinese engineers and businesspeople, especially in the tech sector, are being detained at US airports while border agents inspect their digital devices. The FBI is pursuing econo­mic espionage investiga­tions “that almost invariably lead back to China” in almost every one of its 56 field offices, Wray said.

They’ve made some big arrests. Last year, the agency lured an alleged spymaster affiliated with China’s Ministry of State Security to Belgium, where he was arrested and extradited to the US to face espionage charges. The suspected agent, named Yanjun Xu, allegedly disguised himself as an academic and used LinkedIn to entice a Chinese-American engineer at GE Aviation in Cincinnati to come to China to give a presentation on composite materials for the aerospace industry. The engineer brought along some of his employer’s confidential documents. Xu pleaded not guilty in October and remains in custody in Ohio awaiting trial. The GE Aviation employee wasn’t charged.

Federal agents have also made an alarm­ing number of spy arrests that proved unwar­ranted. From 1997 to 2009, 17 per cent of defendants indicted under the US Econo­mic Espionage Act had Chinese names. From 2009 to 2015, that rate tripled, to 52 per cent, according to a December 2018 article in the Cardozo Law Review. As the number of cases soared, evidence lagged behind. One in five of the Chinese-named defendants was never found guilty of espionage or any other serious crime in the cases between 1997 and 2015 – almost twice the rate of wrongful accusations among non-Chinese defend­ants. The disparity, wrote the paper’s author, Andrew Kim, a visiting scholar at South Texas College of Law at Houston, reflects an apparent bias among federal agents and prosecutors who assume ethnic Chinese scientists must be secretly working for China.

“In the same way racial profiling of African-Americans as criminals may create the crime of ‘driving while black’,” wrote Kim, who practices law at the Houston off­ice of Greenberg Traurig, “profiling of Asian-Americans as spies […] may be creating a new crime: ‘researching while Asian’.”

In 2015, FBI agents stormed the Phila­delphia home of Xiaoxing Xi, a Temple University physicist, and arrested him at gunpoint in front of his wife and two daughters for allegedly sharing super­conduc­tor technology with China. The charges were dropped five months later, after Xi’s lawyers proved the system in question was old and publicly available. But Xi says his life will never be the same. He lost most of his graduate students and research funding and remains preoccupied with fears that the government is still spying on him. “Seeing how such a trivial thing could be twisted into felony charges has had a dramatic psychological impact,” he says. “I was doing academic collaboration that the government, the university, and all the funding agencies encouraged us to do.”

MIT president criticises Washington for ‘unfounded suspicions’ about Chinese academics

Last spring, FBI agents in Houston, armed with a batch of emails from the 23 accounts, knocked on the doors of at least four Chinese-Americans who worked at MD Anderson, asking whether they or others had professional links to China. The agents were particularly interested in scientists connected to China’s Thousand Talents Plan, a government initiative to lure back top scholars from overseas with well-paid jobs in China. A report last year by the US National Intelli­gence Council said the recruitment programme’s underlying purpose is “to facilitate the legal and illicit transfer of US technology, intellectual property and know-how” to China.

“I told them I wasn’t going to snitch,” says one person, who was surprised to find two agents at his back door one afternoon. They told him not to discuss the encounter, says the person, who asked not to be named, and inquired about joint research projects in China. He tried to explain that there are no secrets in basic science, because every­thing gets published. Over their two-hour talk, he says, the agents were less focused on national security issues – say, espionage or trade-secret theft – than on the more soul-searching subject of loyalty. They wanted to know, in effect, are you now or have you ever been more committed to curing cancer in China than in the US? An FBI spokesman wouldn’t comment, but said that the bureau can’t initiate investigations “based solely on an individual’s race, ethnicity, national origin or religion”.

That June, MD Anderson gave the FBI another consent letter, this time permitting it to share any “relevant information” from the cancer centre’s employee accounts with the NIH and other federal agencies. That signalled a new focus for the ostensible national security investigation: compliance with federal grant requirements. It was here that Wu became a target.

US-China trade war could last ‘longer than a generation’

The investigations of the MD Anderson employees were handled by the centre’s compliance chief, Max Weber, and his boss, general counsel Steven Haydon. On the advice of her lawyer, Wu, who had an often-combative relationship with the admini­stra­tion, declined to be interviewed by Weber but submitted written responses to ques­tions. In them she acknowledged lap­ses, but maintained they weren’t duplici­tous. She admitted sharing NIH grant proposals with US colleagues – not to leak scientific secrets, she said, but to get help with her workload. Wu told Weber she used office administra­tors and more junior researchers to perform such tasks as down­loading and printing grant proposals and typing and editing review drafts. Weber concluded that Wu’s use of others to help with grant reviews violated MD Anderson’s ethics policies.

If that’s true, the position is at odds with common practice in academia. “If you sear­ch­ed through MD Anderson or any large research institution, you’d find people with these kinds of compliance issues every­where,” says Lynn Goldman, dean of the Milken School of Public Health at George Washington University. Assisting senior scientists with confidential grant reviews, a rite of passage for many younger research­ers, is considered “part of the mentor­ing process” by older faculty members, Goldman says. “Is it wrong? Probably. Is it a capital offence? Hardly.”

Wu acknowledged accepting various honorary titles and positions in China, such as advisory professor at Fudan University, her alma mater – but she wasn’t paid, she said. She produced emails show­ing she twice withdrew from Thousand Talents consideration, because the posi­tions entailed too much travel. In his report, Weber wrote that Wu failed to disclose com­pensated work at Chinese cancer centres. He offered no proof that she’d been paid, but included potential salary amounts for certain positions in his report, conditioned on “actual work performed”, he wrote. He offered no evidence that she did any work.

Weber based most of his conclusions on “adverse inferences” he drew from Wu’s insistence on responding to his questions in writing. For example, he cited a 2017 article on the website of Shanghai’s Ruijin Hospital that said Wu had been honoured at a ceremony after signing a contract to become a visiting professor. “Given Wu’s failure to appear at her interview, I infer that this fact is true,” Weber wrote.

Yet a week after that article appeared, Wu emailed Ruijin Hospital’s president to say she couldn’t accept the appointment before clearing it with MD Anderson’s conflict-of-interest committee. Twelve days later, she emailed him a draft consulting contract that specified the pact was subject to all rules and regulations of MD Anderson, including those related to intellectual property. “If you agree, I will submit it to our institution for review,” Wu wrote. The Chinese hospital did agree, and she submitted the draft contract to MD Anderson. She never heard back from the conflict-of-interest panel before resigning.

Weber didn’t mention either email in his report. Wu was placed on unpaid leave pending disciplinary action, including possible termination. She quit on January 15. Wu didn’t exercise her right to challenge Weber’s findings at a faculty hearing, Peyton said. “Subsequent protestations of innocence are unfortunate.” Weber didn’t respond to a request for an interview.

To friends and many colleagues, Wu’s case represents overkill. There was no evidence, and no accusation, that she’d given China any proprietary information, whatever that term might mean in cancer epidemiology. She should have been given the chance to correct her disclosures with­out punishment, her supporters say. “Inno­cent yet meaningful scientific collabora­tions have been portrayed as somehow corrupt and detrimental to American interests. Nothing could be further from the truth,” says Randy Legerski, a retired vice-chair of MD Anderson’s genetics depart­ment and former chair of its faculty senate. Adds Goldman of George Washington: “The only thing we’ve lost to China is our investment in Xifeng Wu.”

In an interview, Pisters wouldn’t com­ment on any of the five investigations of Chinese researchers, but said MD Anderson had to act to protect its NIH funding, which reached US$148 million last year. The cancer centre has a “social responsibility” to taxpayers and its donors to protect its intellectual property from any country trying “to take advantage of everything that is aspirational and outstanding in America”, he said.

On a Saturday this March, about 150 ethnic Chinese scientists and engineers packed a University of Chicago conference room for a panel discussion titled, “The New Reality Facing Chinese Americans”. Speakers from the FBI and US attorney’s office assured everyone that multiple layers of government review ensure agents follow the law, not prejudices.

Panellist Brian Sun, partner-in-charge of the Los Angeles office of Jones Day, shot back that prosecutors’ inflammatory rhetoric in Chinese spying cases has repeat­edly stoked public fear, only to have prose­cu­tions collapse. The audience gasped when he described the failed espionage indictment of National Weather Service hydrologist Sherry Chen, who was charged in 2014 with accessing data on US dams to give China. At one point prosecutors said the information could possibly be used during wartime to cause mass murder by blowing up the embank­ments. It turned out that federal investi­ga­­tors knew Chen had legitimate work reasons to retrieve the dam informa­tion, and she never passed any of it to China.

Nancy Chen, a retired federal employee, closed the meeting by raising the unspoken dread in a room full of scholars familiar with the long history of US laws and execu­tive orders aimed at Asian immigrants. “The greatest fear is that history may repeat itself in this political climate, and Chinese-Americans may be rounded up like Japanese-Americans during World War II,” she said. “The fear and worry is real.”

The FBI agent thanked Chen for her comments and said the “atmospheric” information is always good to know.

So far, MD Anderson and Emory Univer­sity, which fired two Chinese-American professors in May, are the only US research institutions known to have parted company with multiple scientists over alleged breach­es of NIH disclosure rules. The University of Wisconsin at Madison rebuffed an FBI request for computer files of a Chinese-American engineering professor without a subpoena, according to a person familiar with the matter. Yale, Stanford and Berkeley, among other institutions, have published letters of support for Chinese faculty mem­bers and research collaborations. “An auto­matic suspicion of people based on their national origin can lead to terrible conse­quences,” wrote Berkeley chancellor Carol Christ in February.

Baylor College of Medicine, located next door to MD Anderson at Houston’s Texas Medical Centre, received NIH inquiries about four faculty members. It didn’t punish anyone, but used the opportunity to correct past disclosure lapses and educate faculty members about more rigorous enforcement going forward, says Kuspa, the school’s research dean. Local FBI activity has rattled enough nerves already, he says. “Chinese scientists have come to me shaking.”

After attending several FBI briefings on the China threat, Kuspa wonders if the bureau understands how long and pains­taking cancer research is. It can take two decades from discovery of a promising molecule to approval of a chemotherapy drug. Even then, progress in cancer treat­ment is measured in months of life, seldom in years. How much basic cancer research could China really steal?

“I joke with my boss after those FBI meetings, ‘Darn, I guess the Chinese are going to cure cancer. I’ll buy that pill,’” Kuspa says. “Isn’t that what we’re supposed to do – educate the entire world to have a fact-based approach to health?”

Additional reporting by Lydia Mulvany and Selina Wang.

Bloomberg Businessweek