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Coronavirus pandemic
ChinaScience

Hunt for Italy’s coronavirus patient zero finds a case in November 2019

  • Peer-reviewed research shows the virus was present in a stored skin sample taken from a Milan woman with a mysterious illness
  • Doctors remembered her when they started to see similar rashes in some Covid-19 patients

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Researchers say they have uncovered what could be Italy’s first case of Covid-19. Photo: EPA-EFE
Stephen Chen
A young woman who visited a Milan hospital with a rash on her arms in November 2019 could be the earliest confirmed case of Covid-19 in Italy, according to a re-examination of sample materials collected at the time.

Raffaele Gianotti, a dermatopathologist with the University of Milan, said Sars-CoV-2 – the virus which causes Covid-19 – had been found in the 25-year-old woman’s preserved skin tissue. She was misdiagnosed with a rare autoimmune disorder, but could now be Italy’s “patient zero”.

The disease was unknown until early January 2020, when Chinese researchers isolated the virus to an outbreak at a seafood market in the central city of Wuhan. Since then, it has been reported across the globe, infecting and killing millions.
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“Our patient could represent the oldest case in literature of detection of the virus on tissue samples,” Gianotti and his collaborators from Spain and Britain said in a peer-reviewed paper published in the British Journal of Dermatology last Thursday.

“Could this case be Italy’s patient zero?”

According to the researchers, the woman had a sore throat but no other symptoms and a thorough examination gave no clue as to the cause of the skin irritation. Her doctors drilled into the rash and obtained a core sample of skin tissue. Finding nothing, they refrigerated the sample.

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