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Coronavirus pandemic
ChinaScience

What are the benefits of a second Covid-19 vaccine booster shot?

  • Some countries have started giving fourth doses to seniors and other vulnerable people
  • But health agencies are still considering whether to expand eligibility to others

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Some countries have started giving fourth shots of Covid-19 vaccines to vulnerable groups such as the elderly. Photo: Jelly Tse
Zhuang Pinghui
When Covid-19 vaccines were being developed and tested two years ago, the idea was to give them either as a two-dose or one-dose regimen, depending on the vaccine.
Now 16 months after the first Pfizer/BioNTech shot went into the arm of an elderly woman in the United States, some countries have started giving fourth doses to seniors and other vulnerable people.

But who needs to take boosters and what are the benefits? Here is what we know so far.

Why do some people need a fourth shot?

Studies show that immunity against the virus that causes Covid-19 wanes over time, irrespective of whether it is induced through infection or vaccination.

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The Omicron variant also dodges vaccines through a structural change on the spike protein, the part of the virus targeted by vaccines.

Various countries have sought to increase vaccine effectiveness against Omicron with booster shots.

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However, a study in February by the US Centres for Disease Control and Prevention found that while mRNA vaccines were highly effective against both moderate and severe cases of Covid-19 for about two months after a third dose, their effectiveness dropped substantially by four months.

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