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Coronavirus pandemic
ChinaScience

Why are diabetic patients at higher risk from Covid-19?

  • A team of Chinese researchers say it could be related to lower levels of a small molecule
  • Supplements might help reduce the danger, they say

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Diabetic patients have higher risk of becoming seriously ill or dying from Covid-19, but the reasons why are not fully understood. Photo: Shutterstock
Zhuang Pinghui

Chinese researchers have found a link between lower levels of a small molecule in diabetic patients and the risk of developing severe Covid-19, saying supplements might be able to help reduce the danger.

Diabetic patients have higher risk of becoming seriously ill or dying from Covid-19, but the reasons why are not fully understood.

In a paper published in the peer-reviewed online journal Nature Metabolism on Monday, the researchers found that supplements of 1,5-AG, a blood biomarker for human diabetes, could reduce replication of the coronavirus in mice.

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“These results indicate that 1,5-AG is an effective anti-Sars-CoV-2 serum metabolite that is downregulated by diabetes,” the authors wrote.

Cheng Gong, a professor at Tsinghua University’s school of medicine and a lead author of the paper, said the study showed diabetes patients could reduce the risk of developing severe Covid-19 by elevating the level of 1,5-AG, and there were different means to do that.

05:44

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“The level of 1,5-AG negatively correlated with blood glucose concentration. Clinically, if the level of blood glucose can effectively be reduced, the level of 1,5-AG will be elevated and reduce the risk of developing Covid-19,” Cheng said.

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