Breakthrough by Hong Kong researchers offers hope people with spinal cord injuries may walk again
HKUST researchers discover way to regenerate damaged spinal cords of lab mice, offering hope to millions of people with long-term injuries
Millions of people around the world paralysed by spinal cord injuries may one day be able to walk again, following a breakthrough by Hong Kong scientists.
Researchers at Hong Kong University of Science and Technology led by Professor Kai Liu have discovered a way to regenerate axons, or nerve fibres, in the spinal cords of mice with long-term injuries.
It's the first time axon regeneration has been induced in the corticospinal tract from injuries at least 12 months old.
"Considering animal life span is two to three years, roughly one year at this stage is comparable to 25 years in a human, so this means it's possible to be applied [to very old injuries]," Liu said.
By removing a gene called PTEN from laboratory mice with chronic spinal injuries, another gene, mTOR, was activated and drove damaged axons to regenerate and re-form connections.
"You can consider the spinal cord is like a highway," Liu said. "So the highway is a bilateral flow, [signals] both going up and down. But once your spinal cord gets disrupted, this information flow gets disrupted [and] both motor and sensory function are gone."