Hong Kong scientists turn salmonella bacteria into ‘guided missiles’ to fight cancer
DNA breakthrough by HKU researchers could lead to new therapy in treating tumours
University of Hong Kong researchers have turned the salmonella food poisoning bacteria into a “guided missile” that could deliver medicine into cancer cells and eliminate tumours.
They have created a DNA-altered bacteria, called YB1, that can only reproduce in oxygen-free conditions. That means it can target malignant tumour growths without harming healthy tissue.
An HKU spokeswoman said: “The researchers hope that [it] can be further developed into a tumour-targeting agent in the near future. The research team is currently exploring other potential use of this new bacterium. It is estimated that YB1 will be ready for clinical trials in a few years.”
They have already applied for patents in different countries through HKU’s Technology Transfer Office, said the spokeswoman. A patent was recently granted in the United States.
Salmonella is a bacteria commonly found in badly cooked meat and raw eggs, causing stomach pains and food poisoning.
But the HKU scientists have engineered the bacteria into a new agent that can only survive in oxygen-deprived areas – such as the inside of a solid tumour.