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Hong KongHealth & Environment

Hong Kong researchers discover crucial piece to mental illness puzzle

A team at Hong Kong University of Science and Technology finds a gene mutation that could eventually lead to a cure for serious mental disorders

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Professor Zhang Mingjie of the Hong Kong University of Science and Technology. Photo: K.Y. Cheng
Emily Tsang

Scientists at Hong Kong University of Science and Technology have identified a gene mutation that leads to mental disorders in a breakthrough discovery that could help find a cure for diseases such as schizophrenia, the university announced on Tuesday.

The findings, published in the journal Neuron, identified the mechanism of the mutation that affects human brains and causes major psychiatric conditions such as bipolar disorder, depression and autism.

While the cause behind the mutation remained unknown, researchers believed the condition could be inherited and later triggered by stress or other environmental factors.

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“Currently, the understanding of the reason behind mental disorders is very limited,” professor Zhang Mingjie, a neuroscientist and structural biologist at the university, said.

Professor Zhang Mingjie at a Hong Kong University of Science and Technology lab. Photo: Dickson Lee
Professor Zhang Mingjie at a Hong Kong University of Science and Technology lab. Photo: Dickson Lee
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“These little steps we, and many other scientists, are now taking are fundamental to laying the foundation for future medical applications that will help save millions of lives.”

In Hong Kong, about 70,000 to 200,000 people are believed to suffer from severe mental illness. Of those, 40,000 were diagnosed with schizophrenia, according to Hospital Authority’s data.

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