Coronavirus mutated 32 times inside South African HIV-positive woman over course of seven months
- If more such cases are found, it raises the prospect that HIV infection could be a source of new variants
- It is not clear whether the mutations the 36-year-old South African carried were passed on to others
The case report, which has not been peer-reviewed, was published as a preprint on medRxiv on Thursday. The woman, who has not been named, was identified as a 36-year-old living in South Africa.
The coronaviruses gathered 13 mutations to the spike protein, which is known to help the virus escape the immune response, and 19 other mutations that could change the behaviour of the virus.
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It is not clear whether the mutations she carried were passed on to others, the Los Angeles Times reported.
If more such cases are found, it raises the prospect that HIV infection could be a source of new variants simply because the patients could carry the virus for longer, Tulio de Oliveira, a geneticist at the University of KwaZulu-Natal in Durban and the study’s author, told the Times.
But it is probably the exception rather than the rule for people living for HIV, because prolonged infection requires severe immunocompromise, Dr Juan Ambrosini, associate professor of infectious diseases at the University of Barcelona, said. Indeed, the woman in the case study was immunosuppressed.
The findings are important for the control of Covid-19 because these patients could be a continuous source of transmission and evolution of the virus, Ambrosini said.