
The Cuban missile crisis unfolded like a life-and-death poker game pitting a young American president, John F Kennedy, against the veteran Soviet leader Nikita Khrushchev and Cuba’s fiery revolutionary leader, Fidel Castro.

The 45-year-old Kennedy, born to privilege and power, had been in office less than two years when he was faced with the worst crisis of the cold war.
His handling of the failed invasion of Cuba in April 1961 – in which he refused additional American military support for anti-Castro forces – convinced his Soviet counterpart that the US president was weak and indecisive, a view reinforced at a summit between the two leaders in Vienna.
Under intense stress, Kennedy was on numerous medications at the time, including steroids for his colitis, procaine for his back pain, testosterone to increase his weight and antibiotics to prevent the return of an old venereal infection.
When the missile crisis erupted, Kennedy had to navigate conflicting advice from his divided cabinet, with hawks pushing for an invasion of Cuba and more cautious aides advocating negotiation.