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Scientists find 400,000-year-old DNA clue to human origins

Scientists say they have retrieved genetic material from a bone dating back 400,000 years, shattering the previous record of 100,000 years

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An artist's rendering shows "the pit of bones" hominins, who are estimated to have lived approximately 400,000 years ago. Photo: AP

Scientists have found the oldest DNA evidence yet of humans' biological history. But instead of neatly clarifying human evolution, the finding is adding new mysteries.

The skeleton of a hominin excavated in Spain. Photo: AP
The skeleton of a hominin excavated in Spain. Photo: AP
In a paper in the journal Nature, scientists reported on Wednesday that they had retrieved ancient human DNA from a fossil dating back about 400,000 years, shattering the previous record of 100,000 years.

The fossil, a thigh bone found in Spain, had previously seemed to many experts to belong to a forerunner of Neanderthals. But its DNA tells a very different story.

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It most closely resembles DNA from an enigmatic lineage of humans known as Denisovans. Until now, Denisovans were known only from DNA retrieved from 80,000-year-old remains in Siberia, 6,400 kilometres east of where the new DNA was found. The mismatch between the anatomical and genetic evidence surprised the scientists, who are now rethinking human evolution over the past few hundred thousand years.

It is possible, for example, that there are many extinct human populations that scientists have yet to discover. They might have interbred, swapping DNA. Scientists hope that further studies of extremely ancient human DNA will clarify the mystery.

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"Right now, we've basically generated a big question mark," said Matthias Meyer, a geneticist at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, and a co-author of the new study.

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