What a brain injury looks like: scientists examine blast victims

Johns Hopkins scientists have discovered what a traumatic brain injury suffered by a quarter million US combat veterans of Iraq and Afghanistan looks like and it's unlike anything they've seen before: a honeycomb pattern of broken connections, primarily in the frontal lobes, our emotional control centre and the seat of our personality.

"In some ways it's a 100-year-old problem," said lead author Vassilis Koliatsos, referring to the shell-shock victims of the first world war, tens of thousands of British soldiers who returned home physically sound but mentally wounded, haunted by their experiences and unable to fully resume their lives.

"When we started shelling each other on the Western Front of World War I it created a lot of sick people … (In a way) we've gone back to the Western Front and created veterans who come back and do poorly and we're back to the Battle of the Somme. They have mood changes, commit suicide, substance abuse … and they really do poorly and can't function. It's a huge problem."

Many of the lingering symptoms of shell-shock, or what today is known as neurotrauma, are the same as they were 100 years ago.

Only the nature of the blast has changed, from high-explosive artillery to Improvised Explosive Devices.

Koliatsos and his team examined the brains of of five recent US combat veterans, all of whom suffered a traumatic brain injury from an IED but died of unrelated causes back home.

He notes that in most Traumatic Brain Injury cases, "their attention is off, mood is off, personality is off. They're impulsive, aggressive, do poorly in school … I wanted to help my patients by trying to understand what is going on in their brains."