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Major global study shows statins can prevent heart attacks and strokes in lower risk patients

The results could prod far more doctors to add a statin to blood pressure therapy for people who have no prior history of heart problems

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With heart disease a leading global killer, causing 18 million deaths each year, there is a trend toward recommending preventive drug treatment to more borderline patients. Photo: SCMP Picture
Agence France-Presse

The first major research of its kind suggested that healthy people may reduce their risk of developing heart problems before they start by taking cholesterol-lowering drugs, known as statins.

The findings came from three trials, which included more than 12,000 people in 21 countries, and were released at the American College of Cardiology conference in Chicago.

Until now, statins have mainly been recommended for people at high-risk of heart disease, which kills 18 million people around the world each year and causes some 50 million heart attacks and strokes.

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“The implications for practice are huge,” said senior researcher Salim Yusuf, professor of medicine at McMaster University.

“I think we certainly should consider using statins much more widely than we have used them thus far.”

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The study used 10 milligrams daily of rosuvastatin, sold as a generic or under the brand name Crestor. The editorial authors said other statins would likely have similar results. Crestor’s maker, AstraZeneca, and the Canadian Institutes of Health Research paid for the study. Photo: AstraZeneca
The study used 10 milligrams daily of rosuvastatin, sold as a generic or under the brand name Crestor. The editorial authors said other statins would likely have similar results. Crestor’s maker, AstraZeneca, and the Canadian Institutes of Health Research paid for the study. Photo: AstraZeneca
The trials, called Heart Outcomes Prevention Evaluation-3 (HOPE-3), were the first of their kind to examine the impact of using statins, sometimes in combination with blood-pressure lowering drugs and other times with a placebo, in a large, globally diverse population.
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