The attack could further sour US-Saudi ties already strained over the coalition’s military intervention which is suspected of causing almost half of the more than 4,000 civilian deaths in Yemen’s conflict.

It also risks embarrassing Washington, which has vehemently criticised Moscow over

the heavy civilian death toll from Russian air raids in support of Syria’s regime in Aleppo city.

In its initial statement, the ­Saudi-led coalition insisted it had no oper­ations at the location and “other causes” for the incident must be considered. However, in a subsequent statement, the coalition said it was ready to launch a probe into the “regrett­able and painful” strike, which the UN said also wounded more than 525 people.

A “horrified and extremely disturbed” UN Under-Secretary General for Humanitarian Affairs and Emergency Relief Coordinator Stephen O’Brien called for a prompt and “impartial” probe into the attacks.

“I also call on all parties to protect civilians and stop using explosive weapons or conducting aerial bombardments in civilian-populated places in Yemen. Surely enough is enough,” he added.

“This horrendous and heinous attack displayed an utter disregard for human life.”

UN chief Ban Ki-Moon called for a “prompt and impartial” probe, insisting that:“Those ­responsible for the attack must be brought to justice.”

In September 2015, a suspected coalition air strike killed at least 131 civilians at a wedding near the Red Sea city of Mokha. The Saudi-led alliance then also denied any involvement.

On Saturday, emergency workers pulled out at least 20 charred remains and body parts from the gutted building in southern Sanaa as others scoured the wreckage for survivors.

Some of the wounded had their legs torn off and were being treated on the spot by volunteers, he said.

In a statement, the Saudi-led coalition said it had no operations at the location and “other causes” for the incident must be considered.

The coalition “has in the past avoided such gatherings and (they) have never been a subject of targeting”, it said.

The insurgent-controlled news site sabanews.net said coalition planes hit after hundreds had gathered to mourn the death of the father of rebel interior minister Jalal al-Rowaishan and denounced the “massacre.”

The Huthis did not say if Rowaishan was present in the building at the time of the attack, nor did they indicate if other senior figures were attending the funeral.

Almasirah said Sanaa mayor Abdel Qader Hilal was among those killed.

The attack could further sour already strained US-Saudi ties.

“We are deeply disturbed by reports of today’s air strike on a funeral hall in Yemen, which, if confirmed, would continue the troubling series of attacks striking Yemeni civilians,” White House National Security Council spokesman Ned Price said in a statement.

“In light of this and other recent incidents, we have initiated an immediate review of our already significantly reduced support to the Saudi-led Coalition and are prepared to adjust our support so as to better align with US principles, values and interests, including achieving an immediate and durable end to Yemen’s tragic conflict.”

Price stressed that “US security cooperation with Saudi Arabia is not a blank check,” and called on all sides to implement an “immediate” ceasefire.

More than 6,700 people - most of them civilians - have been killed in Yemen since the coalition intervened in support of Hadi, according to the United Nations.

Fighting has flared since UN-brokered peace talks between the government and insurgents collapsed in August.

People had come from all over Sanaa to attend the funeral, said Mulatif al-Mojani, who witnessed the latest air strikes.

“A plane fired a missile and minutes later another plane hit” the building where they had gathered, he said.

Another witness, who declined to give his name, angrily described the attack as a “war crime.”

“This was a funeral for one man in Sanaa and now it has turned into a funeral for tens of Yemenis,” he said.

Ambulance sirens blared as they transported the wounded away and residents said local hospitals had issued an appeal for blood donations.

A diplomatic source said that intensified coalition bombing aims “to break” the rebels but warned that “this will not work.”

A UN report in August said coalition air strikes are suspected of causing around half of all civilian deaths in Yemen.

It called for an independent international body to investigate an array of serious violations by all sides, after 4,000 civilians have been killed.

European states led by the Netherlands were defeated last week in a push to establish that inquiry.

The coalition has said it uses highly accurate laser- and GPS-guided weapons and verifies targets many times to avoid civilian casualties.

In addition to the mounting death toll, Yemenis are facing twin health and hunger crises.

The UN’s children agency UNICEF estimates that three million people are in need of immediate food supplies, while 1.5 million children suffer malnutrition.

On Friday, it also reported cases of cholera in Sanaa and third city Taez.